Bacteriophage therapy; Discovery, Alternative to Antibiotics and Challenges

Authors

  • Rameen Atique Department of Pathobiology and Biomedical Sciences, MNS University of Agriculture, 25000, Multan, Pakistan
  • Hafiza Arshi Saeed Department of Pathobiology and Biomedical Sciences, MNS University of Agriculture, 25000, Multan, Pakistan
  • Bushra Anwar Department of Pathobiology and Biomedical Sciences, MNS University of Agriculture, 25000, Multan, Pakistan
  • Tehreem Rana Department of Human Nutrition and Dietetics, MNS University of Agriculture, 25000, Multan, Pakistan
  • Ayesha Haidar Department of Pathobiology and Biomedical Sciences, MNS University of Agriculture, 25000, Multan, Pakistan
  • Ayesha Muazzam Department of Animal Science Gyeongsang National University 501, Jinju-daero, South Korea
  • Javeria Sharif Department of Pathobiology and Biomedical Sciences, MNS University of Agriculture, 25000, Multan, Pakistan
  • Aqsa Perveen Department of Pathobiology and Biomedical Sciences, MNS University of Agriculture, 25000, Multan, Pakistan
  • Hafiza Rida Fatima Department of Pathobiology and Biomedical Sciences, MNS University of Agriculture, 25000, Multan, Pakistan
  • Abdul Samad Department of Animal Science Gyeongsang National University 501, Jinju-daero, South Korea

Keywords:

Bacteriophage, Discovery and History, Clinical experiments, Phage therapy, Substitution for antibiotics, Challenges, Advantages

Abstract

This abstract is a synopsis of the review “Bacteriophage Therapy; Discovery and Alternatives of Antibiotic Therapy”. The term bacteriophage means killer or eater of bacteria. They were initially discovered by F.W. Twort and later on, Felix d'Herelle unveiled them to the world in 1910. Phage therapy has arisen as a favorable option to conventional antibiotics by reducing the multinational problem of increasing antibacterial resistance. These virulent viruses particularly prey on and contaminate bacterial strains and aid in fighting bacterial diseases. Researchers are performing various clinical trials on the bacteriophage to tackle pathogenic bacterial infections, varying from typical illnesses to highly invulnerable biofilms that cannot be treated with antibiotics. The primary experiments demonstrated that phage therapy has fewer consequences than traditional antimicrobial drugs. It is safer to use and show results within a few days. Although phage therapy has a wide range of promising results, but it also encounters diverse obstacles. One is that they are host-specific and can merely be used for personalized therapy. As thousands of bacteria can cause disease, clinicians have to construct a library of phage viruses. For successful treatment, an analysis of versatility, stability, and immune interference related to bacteriophage is necessary. Phage therapy is an excellent substitute for antibiotics as it illustrates a living base for the treatment of infections and it is climate-friendly. It only targets the pathogenic cells and has less influence on the normal microbiota. Regardless of the challenges and problems, phage therapy is approved as a beneficial approach to combating the contagious infections.

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Published

2024-11-22